Young Professional from the West Coast Moving to Philly. Where's the Best Neighborhood?

That depends who you ask, as there are many options. I lived near Philly all my life, but only rented one year in the city when my family was younger. That neighborhood became more ghetto in the last 25 years, sadly. Other neighborhoods have become a bit gentrified. My son and daughter in law went to Drexel U., and stayed near the University City neighborhood, and Powelton Village for a few years. That is on the edge of Center City, and the beginning of West Philly (West, which is not so great in parts or dangerous). Many of their fellow grads stayed on in parts of the city, too, but some too high in rent for them. They then moved on to the "Northeast", but had to move again to another section when their rent was raised. They now rent a rowhome in Holmesburg, which is ok for now as they save for a house. Some of the more hipster type housing is near Center City, with places like Fishtown really changing, and of course near South Street. You might have to look for a roomate depending on the area. I suggest read up on line, look for apt. after you get here to get the feel of the neighborhood.