Are there any big chain stores in North East?

The closest thing you're going to get to a chain store in North East is a CVS in Millerton hamlet. Aside from that, all the retail businesses here are small and local.

If I lived in North East, I'd say the closest place where I know for certain you'll find chain stores (like a K-Mart, for example) is in Great Barrington, MA. That's probably at least half an hour away. Your other option would probably be Poughkeepsie's malls, which are close to an hour away from here.